In my research, I delved into the comprehensive characterization of Epidermal Growth Factor Receptor (EGFR) expression within a specific cohort of Indian Triple-Negative Breast Cancer (TNBC) patients. This investigation aimed to elucidate the molecular nuances and variations in EGFR expression patterns, contributing valuable insights into the unique aspects of TNBC within the Indian population. The findings have potential implications for personalized treatment strategies and advancements in our understanding of the molecular landscape of breast cancer in this demographic.

For my master's project, I delved into comprehending the pivotal role played by YAP in the oncogenicity induced by HER2. Additionally, my research encompassed a thorough exploration of HER3 expression within breast epithelial cell lines. This multifaceted investigation allowed me to unravel intricate molecular interactions and gain deeper insights into the complex mechanisms governing oncogenic processes, particularly in the context of HER2 and HER3 signaling pathways in breast cancer.

Aadya focused on her Master's thesis, "Exploring Metabolism-Associated YAP-Signature Targets in Mammary Epithelium Cell Line." As a Project Assistant, she contributed to the DST-funded project "Investigation of regulation of YAP-driven tumorigenesis by promoter proximal pausing." In the lab, she mastered diverse techniques, including mammalian cell culture, molecular biology (RT-PCR, DNA gel electrophoresis, SDS-PAGE, Western Blotting), microbiology, immunohistochemistry, imaging, and animal handling.

I delved into clinical tumor biology for my Master's thesis, guided by Dr. Kulkarni. The focus was on investigating Yes-associated protein (YAP) as a prognostic marker for TNBC in the Indian Cohort. This marked my first independent project leadership, involving experiment design, data analysis, and active discussions for feedback. Subsequently, we explored TCGA data, evaluating YAP expression across breast cancer subtypes. Presenting my work at the TCGA international conference in India earned me the best poster award.

In my research, I delved into the intricate interplay between YAP and growth factor receptor signaling to unravel their contributions to breast cancer advancement. Utilizing a diverse array of investigative tools, including cell culture assays, molecular biology techniques, microscopy, and mouse xenograft models, I aimed to gain comprehensive insights. Beyond the experimental realm, I actively contributed to maintaining the laboratory environment and provided mentorship to junior team members, fostering a collaborative and productive research atmosphere.

Utilized advanced high-resolution microscopy techniques to capture detailed images of breast tumor microsections featuring diverse biomarker stains. Employed ImageJ/FIJI software for meticulous analysis, facilitating in-depth examination of stained breast cancer tissues. This methodology served crucial research objectives, enhancing our understanding of the intricate molecular characteristics within these tissues for potential advancements in breast cancer diagnosis and treatment strategies.

As a student at Ahmedabad University, I dedicated August 2018 to June 2019 to a crucial research project for my master's thesis. Teaming up with Madhura at IISER Pune, we delved into YAP's significance as a prognostic marker in HER2 positive breast cancer. This academic pursuit deepened my understanding of cancer markers and their clinical implications, offering a meaningful contribution to the field.

Conducted in-depth research on resistance mechanisms to anti-HER2 drugs in HER2-positive breast cancer patients. Analyzed complex data sets, conducted literature reviews, and collaborated with a multidisciplinary research team. This enhanced my proficiency in molecular biology, oncology, and data interpretation. Our findings contribute to advancing personalized medicine and optimizing treatment for HER2-positive breast cancer, fostering progress in cancer research.

I have completed my M.Tech in Biotechnology from Dr. D Y Patil Biotechnology and Bioinformatics, Pune. My interest in cancer biology made me join CTCR. Currently I am working on YAP and PPP project. Outside research I also enjoy badminton, swimming, reading fiction novels.